Week 2 is loaded with intriguing matchups, and bettors have plenty of angles to consider as teams start to show their true form after opening week. From early overreactions in the market to key injuries, this weekend offers opportunities for sharp plays across both team and player markets. Using BTA Sports’ projections, here are my top 5 betting insights for Sunday’s slate:
1. Banged Up 49ers Favored Over The Saints
San Francisco enters Week 2 severely shorthanded, with Brock Purdy sidelined for multiple weeks, George Kittle landing on IR, and Jauan Jennings uncertain after a shoulder scare. That leaves the 49ers offense in the hands of a backup quarterback, a depleted receiving corps, and a run game likely to carry the load. They face off against Spencer Rattler and the Saints, who were named a bottom-tier team entering the season. Our model predicts that the injuries won’t be enough to stop the 49ers from taking this game.
- Spread:
- Vegas: New Orleans +3.0
- BTA: New Orleans +8.42
- Total:
- Vegas: O/U 40.5
- BTA: O/U 42.76
2. Can Daniel Jones Repeat Perfection?
Daniel Jones wasted no time making an impact in his Colts debut, leading them to become the first team since 1977 to score on EVERY offensive possession in a game. He spread the ball efficiently, added scores with both his arm and legs, and gave Indianapolis an offensive spark they’ve been missing. He enters Week 2 against a top defense in Denver, which held rookie Cam Ward to just 112 passing yards in his debut.
- BTA Projections:
- 200+ Passing Yards (73.80%)
- 250+ Passing Yards (43.75%)
- 1+ Passing TD (86.02%)
- 2+ Passing TD (58.48%)
- 3+ Passing TD (31.85%)
3. Get-Right Game For Detroit
The Detroit Lions are looking to shake off a sluggish Week 1 and get back on track against the Bears. Jared Goff and the offense need to find rhythm after accounting for just 246 total offensive yards, while the defense aims to tighten up and control the line of scrimmage. The biggest storyline for this game will be the Lions facing former OC Ben Johnson, now calling plays for Chicago, which could make for an intense chess match. The Lions are expected to be winners, having won 5 of their last 6 matchups.
- Spread:
- Vegas: Detroit -6.0
- BTA: Detroit -8.91
- Total:
- Vegas: O/U 46.5
- BTA: O/U 43.87
4. Super Bowl Rematch in Kansas City
The Eagles and Chiefs meet this week in a highly anticipated Super Bowl rematch, with revenge and bragging rights on the line. Philadelphia enters with momentum after a divisional victory over the Cowboys, as Jalen Hurts showcased his dual-threat ability and the defense held strong in the second half. Kansas City is looking to bounce back from the loss to the Chargers in Brazil. While Vegas expects this game to be a toss-up, our models suggest a two-score victory for the Birds.
- Spread:
- Vegas: Kansas City +1.0
- BTA: Kansas City +8.5
- Total:
- Vegas: O/U 47.0
- BTA: O/U 39.74
5. Burrow/Chase Bounce Back
Joe Burrow and Ja’Marr Chase enter Week 2 after the Bengals’ narrow 17–16 victory over the Cleveland Browns last week. Burrow completed 14 of 23 passes for 113 yards and a touchdown, showcasing efficiency but limited yardage. Chase, who was most likely the #1 pick in your fantasy draft, recorded 2 receptions for just 26 yards. They look to bounce back on Sunday against the Jacksonville Jaguars, a team that has recently struggled against Cincinnati.
- Joe Burrow BTA Projections:
- 200+ Passing Yards (74.17%)
- 250+ Passing Yards (59.60%)
- 300+ Passing Yards (25.90%)
- 2+ Passing TD (74.28%)
- 3+ Passing TD (50.48%)
- Ja’Marr Chase BTA Projections:
- 75+ Receiving Yards (72.40%)
- 100+ Receiving Yards (43.70%)
- 5+ Receptions (89.30%)
- 8+ Receptions (52.83%)
- To Score A Touchdown (57.13%)
